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Organized structure of real-world evidence best practices: moving from fragmented recommendations to comprehensive guidance
Decision-makers have become increasingly interested in incorporating real-world evidence ...
Key Learnings from ICER’s Real World Evidence Reassessment Pilot
Health technology assessment (HTA) agencies are considering adopting a lifecycle approach ...
Safety of Intravenous Pantoprazole Sodium in Pediatric Patients Aged 1 Month to < 1 Year: A Real-World Retrospective Cohort Study
Objective To estimate the incidence rates (IR) of prespecified outcomes of interest in ...
Using Healthcare Databases to Replicate Trial Findings for Supplemental Indications: Adalimumab in Patients with Ulcerative Colitis
Regulators wish to understand whether real world evidence can be used for secondary ...
Prevalence and Incidence of Chronic Fibrosing Interstitial Lung Diseases with a Progressive Phenotype in the United States Estimated in a Large Claims Database Analysis
Introduction Many fibrosing interstitial lung diseases (ILDs) develop a chronic ...
Real-world effectiveness of early intervention with fixed-dose tiotropium/olodaterol vs tiotropium in Japanese patients with COPD: a high-dimensional propensity score–matched cohort analysis
Background Escalation to triple therapy (long-acting muscarinic antagonist/β2-agonist, ...
Clinical features and diagnosis of multiple myeloma: a population-based cohort study in primary care
Objectives Patients with multiple myeloma (MM) experience significant delays in diagnosis ...
Real‐world reproducibility study characterizing patients newly diagnosed with multiple myeloma using Clinical Practice Research Datalink, a UK‐based electronic health records database
Purpose We evaluated the reproducibility of a study characterizing newly-diagnosed ...
Fournier's gangrene in patients with type 2 diabetes using second‐line antidiabetic medications
Cases of a rare but serious infection called Fournier's gangrene have been reported with ...
COVID-19 Evidence Accelerator: A parallel analysis to describe the use of Hydroxychloroquine with or without Azithromycin among hospitalized COVID-19 patients
Background The COVID-19 pandemic remains a significant global threat. However, despite ...
Chronic opioid use and complication risks in women with endometriosis: a cohort study in US administrative claims
Background Women with endometriosis are prescribed opioids for pain relief but may be ...
Using primary care data to assess comparative effectiveness and safety of apixaban and rivaroxaban in patients with nonvalvular atrial fibrillation in the UK: an observational cohort study
Objective To compare real-world effectiveness and safety of direct oral anticoagulants ...
Availability of comparative real-world evidence research in Medicare patients: Implications for CMS drug price negotiations
To evaluate the availability of published comparative real-world evidence (RWE) studies ...
Statin Use and Severe Acute Liver Injury Among Patients with Elevated Alanine Aminotransferase
While serious liver injury among statin users is extremely rare, baseline liver enzyme ...
Incorporating linked healthcare claims to improve confounding control in a study of in-hospital medication use
Introduction The Premier Perspective hospital billing database provides a promising data ...
Empirical assessment of case‐based methods for drug safety alert identification in the French National Healthcare System database (SNDS): Methodology of the ALCAPONE project
Objectives To introduce the methodology of the ALCAPONE project. Background The French ...
Cardiovascular and Renal Outcomes in Patients with Type-2 Diabetes and Chronic Kidney Disease Identified in a United States Administrative Claims Database: A Population Cohort Study
Introduction: CKD, a common complication of type-2 diabetes (T2D), causes considerable ...
Real‐world evidence on bariatric surgery and cardiovascular benefits using electronic health record data: A lesson in bias
Aim To reproduce and correct studies on bariatric surgery and the reduction in major ...
Use of systemic immunomodulating medications in pregnant women with atopic dermatitis: a nationwide US study
No abstract available
Transparency and reproducibility of observational cohort studies using large healthcare databases.
The scientific community and decision-makers are increasingly concerned about ...
Healthcare resource utilization, costs and treatment associated with myasthenia gravis exacerbations among patients with myasthenia gravis in the US: A retrospective analysis of claims data
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Visualizations throughout pharmacoepidemiology study planning, implementation, and reporting
Transparency is increasingly promoted to instill trust in nonrandomized studies using ...
Durability of the Single-Dose Ad26.COV2.S Vaccine in the Prevention of COVID-19 Infections and Hospitalizations in the US Before and During the Delta Variant Surge
Importance Vaccination against the SARS-CoV-2 virus is critical to control the pandemic. ...
Empirical assessment of case‐based methods for identification of drugs associated with acute liver injury in the French National Healthcare System database (SNDS)
Purposes Drug induced acute liver injury (ALI) is a frequent cause of liver failure. ...