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Feb 14, 2023
Learning from the past to advance tomorrow's real world evidence: what demonstration projects have to teach us.
Regulators, health technology assessment (HTA) agencies, and payers are actively ...
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Publication
Feb 14, 2023
A Descriptive Cohort Study of Drug Utilization Patterns Among Patients Hospitalized With Coronavirus Disease 2019 in the United States, January 2021–February 2022
Background There is a dearth of drug utilization studies for coronavirus disease 2019 ...
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Publication
Feb 14, 2023
Healthcare Resource Utilization and Baseline Characteristics of Patients With Generalized Pustular Psoriasis: Real-World Results From a Large US Database of Multiple Commercial Medical Insurers
Background: Generalized pustular psoriasis (GPP) is a rare, severe neutrophilic skin ...
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Feb 14, 2023
Clinical Burden of Concomitant Joint Disease in Psoriasis: A US-Linked Claims and Electronic Health Records Database Analysis
Background Few studies have evaluated the clinical burden of concomitant joint disease in ...
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Publication
Feb 14, 2023
Clinical characteristics and healthcare resource utilization in patients with generalized pustular psoriasis: real-world evidence from a large claims-based dataset
Background: Generalized pustular psoriasis (GPP) is a rare, severe neutrophilic skin ...
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Publication
Feb 14, 2023
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
INTRODUCTION The emergence of three lethal coronaviruses in <20 years and the urgency ...
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Feb 14, 2023
First Maintenance Therapy for Chronic Obstructive Pulmonary Disease: Retrospective Analyses of US and UK Healthcare Databases
Introduction Inhaled corticosteroids (ICS) are often prescribed inappropriately alongside ...
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Feb 14, 2023
Healthcare utilization of patients with hereditary angioedema treated with lanadelumab and subcutaneous C1-inhibitor concentrate
Background: New hereditary angioedema (HAE) treatments have become available in recent ...
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Publication
Feb 14, 2023
Emulating Randomized Clinical Trials With Nonrandomized Real-World Evidence Studies: First Results From the RCT DUPLICATE Initiative.
Background: Regulators are evaluating the use of noninterventional real-world evidence ...
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Publication
Feb 14, 2023
iGlarLixi vs. premixed insulin initiation in adults with type 2 diabetes advancing from basal insulin therapy: SoliComplex real-world study
Aim To compare outcomes in adults with type 2 diabetes (T2D) suboptimally controlled with ...
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Publication
Feb 14, 2023
Evaluation of VTE, MACE, and serious infections among patients with RA treated with baricitinib compared to TNFi: a multi-database study of patients in routine care using disease registries and claims
Introduction The aim of this work is to evaluate baricitinib safety with respect to ...
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Publication
Feb 14, 2023
Effects of expanding the look‐back period to all available data in the assessment of covariates
Background A fixed baseline period has been a common covariate assessment approach in ...
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Feb 14, 2023
Transferability of real-world data across borders for regulatory and health technology assessment decision-making
Recently, there has been increased consideration of real-world data (RWD) and real-world ...
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Publication
Feb 14, 2023
Diagnosis-wide analysis of COVID-19 complications: an exposure-crossover study
Background: Many studies reporting coronavirus disease 2019 (COVID-19) complications have ...
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Publication
Feb 14, 2023
Adherence to Chronic Kidney Disease Screening Guidelines Among Patients With Type 2 Diabetes in a US Administrative Claims Database
Objective To examine the screening rates for kidney damage and function among patients ...
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Publication
Feb 14, 2023
SURF: A Screening tool (for manufacturers) to evaluate whether Using real-world data to support an effectiveness claim in an FDA application has Regulatory Feasibility
Based on recent guidance and publicly available approvals, the US Food and Drug ...
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Feb 14, 2023
The Structured Process to Identify Fit-For-Purpose Data: A Data Feasibility Assessment Framework
To complement real-world evidence (RWE) guidelines, the 2019 Structured Preapproval and ...
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Feb 14, 2023
Characteristics of adults newly diagnosed with idiopathic hypersomnia in the United States
Background Idiopathic hypersomnia is a debilitating sleep disorder; however, little is ...
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Publication
Feb 14, 2023
[RCT-D] Non-randomized healthcare database studies and their agreement with 32 emulated randomized controlled trials
Importance Nonrandomized studies using insurance claims databases can be analyzed to ...
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Feb 14, 2023
The Aetion Coalition to Advance Real-World Evidence through Randomized Controlled Trial Emulation (CARE) Initiative: Oncology
Legislative and technological advancements over the past decade have given rise to the ...
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Feb 14, 2023
Drug utilization patterns and adherence in patients on systemic medications for the treatment of psoriasis: A retrospective, comparative cohort study
Background: Nonadherence to systemic treatments for psoriasis leads to treatment failure ...
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Feb 14, 2023
Advancing digital health applications: priorities for innovation in real-world evidence generation
In 2019, Germany passed the Digital Healthcare Act, which, among other things, created a ...
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Feb 14, 2023
"An epidemiological model to estimate the prevalence of diffuse large B-cell lymphoma in the United States"
Background: Prevalence is reflective of disease incidence and survival, and defined as ...
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Feb 14, 2023
Single-arm oncology trials and the nature of external controls arms
Aim: Single-arm trials with external control arms (ECAs) have gained popularity in ...
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